Royal Society Research Fellow
Tung Le studies how the chromosome is organised spatially and segregated faithfully, using a simplified bacterial system. This process is essential allowing daughter cells to inherit a full copy of the genetic information.
Tung uses next-generation sequencing and computational modelling to map the three-dimensional structure of the chromosome in an aquatic bacterium called Caulobacter crescentus.
His group is also investigating how the conserved Structural Maintenance of Chromosomes (SMC) protein packages the chromosome inside the cells.
- Next-generation sequencing and computational modelling
- DNA replication, segregation and DNA-damage repair
- SMC proteins for designing synthetic artificial chromosome