Cyclic di-GMP prevents sporulation in Streptomyces bacteria
Streptomyces bacteria are our primary source of antibiotics, which are produced in the transition from vegetative growth to sporulation in a complex developmental life cycle.
Previous research by Professor Mark Buttner’s lab at the John Innes Centre has shown that the signalling molecule c-di-GMP binds BldD, a master repressor of gene activity, to control the initiation of development in these soil-dwelling bacteria.
c-di-GMP is an example of a nucleotide second messenger, an intracellular signal widespread in bacteria responsible for regulating crucial processes, including mobility, virulence and biofilm formation.
In a new study, experiments using the model species Streptomyces venezuelae show that c-di-GMP also intervenes later in development to control the differentiation of the reproductive hyphae into spores.
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The proteins that maintain formicamycin biosynthesis fidelity
Formicamycins are a set of antibiotics produced by the bacteria Streptomyces formicae that have shown useful activity against antibiotic resistant strains of the pathogenic bacteria Staphyloccus aureus.
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Microbiology Society Outreach Prize awarded to Matt Hutchings
PROFESSOR MATT HUTCHINGS WINS THE 2019 MICROBIOLOGY OUTREACH PRIZE
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