Group Leader
We aim to reconstruct intestinal cell, microbial strain, disease and patient specific signalling and regulatory networks, and integrate them in a multiscale system containing both host cells and microbes to understand molecular (patho)mechanisms.
Our key interests are the role of autophagy in intestinal inflammation and cancer, the systems biology of ulcerative colitis (a type of inflammatory bowel disease), and microbial rewiring of host regulatory processes.
The group combines in silico network biology methods with experimental validation and ‘omics approaches to explore and understand how pathogen and commensal microbes are affecting host processes.