Research Group Leader
Streptomyces development
Mark works on the control of development in the antibiotic-producing bacteria Streptomyces.
His lab has established S. venezuelae as a new model species for the genus because it sporulates in liquid culture. This greatly facilitates the application of global ‘omics’ approaches to the study of development, and allows movies to be made of the complete spore-to-spore lifecycle.
Mark also uses Streptomyces superhost strains to express antibiotic gene clusters heterologously.
- Developmental research into sporulation in Streptomyces
- Sporulation in liquid culture
- Streptomyces superhosts for heterologous expression of antibiotic gene clusters.